Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.

@article{Dubnicoff1997ConversionOD,
  title={Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.},
  author={T Dubnicoff and S A Valentine and Gong Chen and Taiping Shi and Judith A. Lengyel and Ze'ev Paroush and Albert J. Courey},
  journal={Genes & development},
  year={1997},
  volume={11 22},
  pages={2952-7}
}
The Dorsal morphogen acts as both an activator and a repressor of transcription in the Drosophila embryo to regulate the expression of dorsal/ventral patterning genes. Circumstantial evidence has suggested that Dorsal is an intrinsic activator and that additional factors (corepressors) convert it into a repressor. These corepressors, however, have previously eluded definitive identification. We show here, via the analysis of embryos lacking the maternally encoded Groucho corepressor and via… CONTINUE READING

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