Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship.

@article{Zeisel1989ConversionOD,
  title={Conversion of dietary choline to trimethylamine and dimethylamine in rats: dose-response relationship.},
  author={Steven H Zeisel and K A daCosta and Mounira Youssef and S Hensey},
  journal={The Journal of nutrition},
  year={1989},
  volume={119 5},
  pages={800-4}
}
Trimethylamine (TMA) and dimethylamine (DMA) are normal components of human urine and are precursors of dimethylnitrosamine, a potent carcinogen. In part, DMA and TMA are products of the metabolism of dietary choline by intestinal bacteria. Most TMA formed in the intestinal tract is later oxidized and excreted as trimethylamine oxide (TMAO). Humans treated with large doses of choline smell "fishy" (the odor of TMA). Humans ingest choline as part of foods, and yet rarely smell fishy, suggesting… CONTINUE READING
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