Conversion of cerebral cortex into basal ganglia in Emx2−/− Pax6Sey/Sey double-mutant mice

@article{Muzio2002ConversionOC,
  title={Conversion of cerebral cortex into basal ganglia in Emx2−/− Pax6Sey/Sey double-mutant mice},
  author={L. J. Muzio and Barbara Di Benedetto and Anastassia Stoykova and E. Boncinelli and P. Gruss and Antonello Mallamaci},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={737-745}
}
The molecular mechanisms that activate morphogenesis of cerebral cortex are currently the subject of intensive experimental analysis. Transcription factor genes of the homeobox, basic helix-loop-helix (bHLH) and zinc-finger families have recently been shown to have essential roles in this process. However, the actual selector genes activating corticogenesis have not yet been identified. Here we show that high-level expression of at least one functional allele of either of the homeobox genes… CONTINUE READING
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