Conversion of bacterially expressed recombinant prion protein.

  title={Conversion of bacterially expressed recombinant prion protein.},
  author={Fei Wang and Xinhe Wang and Jiyan Ma},
  volume={53 3},
The infectivity associated with prion disease sets it apart from a large group of late-onset neurodegenerative disorders that shares the characteristics of protein aggregation and neurodegeneration. The unconventional infectious agent, PrP(Sc), is an aberrantly folded form of the normal prion protein (PrP(C)) and the PrP(C)-to-PrP(Sc) conversion is a critical pathogenic step in prion disease. Using the Protein Misfolding Cyclic Amplification technique, we converted folded bacterially expressed… CONTINUE READING

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