Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin.

@article{Casey2008ConversionOA,
  title={Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin.},
  author={Laurieann Casey and Erin E Patterson and Ulrika M{\"u}ller and Catherine A Fox},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 2},
  pages={
          608-22
        }
}
Silencing of the mating-type locus HMR in Saccharomyces cerevisiae requires DNA elements called silencers. To establish HMR silencing, the origin recognition complex binds the HMR-E silencer and recruits the silent information regulator (Sir)1 protein. Sir1 in turn helps establish silencing by stabilizing binding of the other Sir proteins, Sir2-4. However, silencing is semistable even in sir1Delta cells, indicating that SIR1-independent establishment mechanisms exist. Furthermore, the… CONTINUE READING
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