Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.

  title={Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.},
  author={Michio Tomishige and Dieter Robert Klopfenstein and Ronald D. Vale},
  volume={297 5590},
Unc104/KIF1A belongs to a class of monomeric kinesin motors that have been thought to possess an unusual motility mechanism. Unlike the unidirectional motion driven by the coordinated actions of the two heads in conventional kinesins, single-headed KIF1A was reported to undergo biased diffusional motion along microtubules. Here, we show that Unc104/KIF1A can dimerize and move unidirectionally and processively with rapid velocities characteristic of transport in living cells. These results… CONTINUE READING
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