Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.

@article{Niebuhr2002ConversionOP,
  title={Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.},
  author={Kirsten Niebuhr and Sylvie Giuriato and Thierry P{\'e}dron and Dana J Philpott and Fr{\'e}d{\'e}rique Gaits and Julia E Sable and Michael P Sheetz and Claude Parsot and Philippe J Sansonetti and Bernard Payrastre},
  journal={The EMBO journal},
  year={2002},
  volume={21 19},
  pages={5069-78}
}
Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4-phosphatase that specifically dephosphorylates phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2)] into phosphatidylinositol 5-monophosphate [PtdIns(5)P] that… CONTINUE READING
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