Conversion of L‐tryptophan to serotonin and melatonin in human melanoma cells
@article{Slominski2002ConversionOL, title={Conversion of L‐tryptophan to serotonin and melatonin in human melanoma cells}, author={Andrzej T. Slominski and Igor V Semak and Alexander V. Pisarchik and Trevor W. Sweatman and Andre Szczesniewski and Jacobo Wortsman}, journal={FEBS Letters}, year={2002}, volume={511} }
130 Citations
The expanding roles of 1‐methyl‐tryptophan (1‐MT): in addition to inhibiting kynurenine production, 1‐MT activates the synthesis of melatonin in skin cells
- BiologyThe FEBS journal
- 2013
It is reported that melatonin biosynthesis is driven by 1‐methyl‐tryptophan (1‐MT), a competitive inhibitor of IDO1, in human fibroblasts, melanocytes and melanoma cells, and it was observed that 1‐MT, as well melatonin, inhibited the proliferation of human melanomas cells.
Serotoninergic and melatoninergic systems are fully expressed in human skin
- Biology, MedicineFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2002
Examination of cutaneous expression of genes and enzymes responsible for the multistep conversion of tryptophan to serotonin and further to melatonin provides evidence that the human skin expresses intrinsic serotonin and melatonin biosynthesis pathways.
Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells
- Biology, MedicineFASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2013
The metabolism of melatonin and its endogenous production is cell type‐dependent and expressed in all three main cell populations of human skin and stimulate differentiation in human epidermis, indicating their key role in building the skin barrier.
Characterization of serotonin and N‐acetylserotonin systems in the human epidermis and skin cells
- Biology, MedicineJournal of pineal research
- 2019
A serotonin‐NAS system in human skin that is a part of local neuroendocrine system regulating skin homeostasis is characterized and produced endogenously in the epidermal, dermal, and adnexal compartments of human skin and in cultured skin cells.
Characterization of the serotoninergic system in the C57BL/6 mouse skin.
- Biology, ChemistryEuropean journal of biochemistry
- 2003
Mouse skin has the molecular and biochemical apparatus necessary to produce and metabolize serotonin and N-acetylserotonin, and its activity is determined by topography, physiological status of the skin, cell type and mouse strain.
Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro
- BiologyMolecular and Cellular Endocrinology
- 2015
Up‐regulation of melanin synthesis by the antidepressant fluoxetine
- BiologyExperimental dermatology
- 2012
The results suggest that fluoxetine may hold a significant therapeutic potential for treating skin hypopigmentation disorders, and SR1A may serve as a novel target in modulating melanogenesis.
Expression of genes coding melatonin and serotonin receptors in rodent skin.
- Biology, PsychologyBiochimica et biophysica acta
- 2004
Functional activity of serotoninergic and melatoninergic systems expressed in the skin
- BiologyJournal of cellular physiology
- 2003
Skin cells represent a true target for the products of the serotoninergic/melatoninergic cutaneous pathway with their actions modulating cell proliferation or viability, according to cell type and culture conditions.
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Since the hamster amelanotic melanoma line shows profound metabolic and cellular changes accompanying the induction of melanin synthesis by DMEM or L-tyrosine, it is tested whether the changes in pigmentation level in human melanoma cells are similarly accompanied by increased expression of tyrosinasc and MC1R genes.
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