Conversion of Angiotensin I to Angiotensin II

@article{Ng1967ConversionOA,
  title={Conversion of Angiotensin I to Angiotensin II},
  author={K. K. F. Ng and John Robert Vane},
  journal={Nature},
  year={1967},
  volume={216},
  pages={762-766}
}
  • K. Ng, J. Vane
  • Published 25 November 1967
  • Biology, Engineering
  • Nature
Results obtained with the blood bathed organ technique indicate that angiotensin I is converted rapidly to angiotensin II in the pulmonary circulation and not by an enzyme in the blood. 
Fate of Angiotensin I in the Circulation
TLDR
The results of the blood-bathed organ technique do not support hypotheses which suggest a completely intra-renal role for the renin–angiotensin system.
The Renin–Angiotensin System: Inhibition of Converting Enzyme in Isolated Tissues
The converting enzyme content of isolated tissues suggests that the indirect action of angiotensin I involves the intramural generation of angiotensin II. Inhibition of the enzyme shows that there is
Metabolism of the Angiotensins in Isolated Perfused Tissues
TLDR
Enzymes in isolated vascular beds can fully account for the metabolism of angiotensins I and II in vivo and may not be physiologically important.
Conversion of Angiotensin I to II In Vivo and In Vitro
TLDR
This work has shown that the major site of conversion was the pulmonary circulation and that conversion in plasma could not account for the rapid pressor response to an intravenous injection of AI.
Hepatic conversion of angiotensin I and the portal hypertensive response to angiotensin II in normal and regenerating liver
TLDR
The purpose was to characterize angiotensin I liver conversion and show that the liver is able to convert AI into AII to trough the action of the ang Elliotensin‐converting enzyme (ACE).
Conversion of angiotensin I to angiotensin II.
Pulmonary activation of synthetic angiotensin I.
Pressor Response to Angiotensins I and II and Renin in Rats treated with Carbon Tetrachloride
TLDR
These investigators postulated that the converting enzyme may be located on or in the pulmonary cells of the lung, and proposed the liver as a probable site of synthesis for the plasma enzyme.
Angiotensin-dependent hypertension--potential pitfalls in definition.
  • G. Williams
  • Medicine
    The New England journal of medicine
  • 1977
TLDR
In an attempt to resolve this controversy, interruption of the renin-angioten...
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It is now clear that the blood itself plays little part in the inactivation of angiotensin and that the rapid removal of ang Elliotensin from the bloodstream occurs in the tissues through which it is carried.
THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME
It has been shown by use of isolated, perfused rat kidneys that hypertensin II is a potent vasoconstrictor substance while hypertensin I is not. Hence it would appear that in intact animals the
A SENSITIVE METHOD FOR THE ASSAY OF ANGIOTENSIN.
TLDR
Under the conditions of the assay, the preparation is sensitive to angiotensin and relatively insensitive to 5-hydroxytryptamine, to histamine and to other substances which might be present in blood.
5-Hydroxytryptamine in the Circulation of the Dog
Estimation of the relative importance of platelets, lungs, liver and peripheral vascular beds in removing this amine from the circulation of the dog shows that the lungs are most active in this
THE PURIFICATION OF HYPERTENSIN I
TLDR
Acid hydrolysis and paper chromatography indicate in a preliminary fashion that there are about nine amino acids present in the intact polypeptide.
Polypeptides which Affect Smooth Muscles and Blood Vessels: (A Symposium), M. Schachter, M.D., Sc.D., University College, London, Editor. 336 + xv pages, illustrated. New York, Pergamon Press, Inc., 1960. $8.50
TLDR
This book contains the proceedings of an international symposium held in London in 1959 that appeared in print under the competent editorship of J. H. Gaddum and bore the title Polypeptides which Stimulate Plain Muscle.