Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System*

@article{Hgesttt2005ConversionOA,
  title={Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System*},
  author={Edward D. H{\"o}gest{\"a}tt and Bo A. G. Jönsson and Anna Ermund and David A. Andersson and Henrik Bj{\"o}rk and Jessica P Alexander and Benjamin F. Cravatt and Allan I. Basbaum and Peter M. Zygmunt},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={31405 - 31412}
}
Acetaminophen (paracetamol) is a popular domestic analgesic and antipyretic agent with a weak anti-inflammatory action and a low incidence of adverse effects as compared with aspirin and other non-steroidal anti-inflammatory drugs. Here we show that acetaminophen, following deacetylation to its primary amine, is conjugated with arachidonic acid in the brain and the spinal cord to form the potent TRPV1 agonist N-arachidonoylphenolamine (AM404). This conjugation is absent in mice lacking the… Expand
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