Conversion of α‐Amino Acids into Nitriles by Oxidative Decarboxylation with Trichloroisocyanuric Acid

  title={Conversion of $\alpha$‐Amino Acids into Nitriles by Oxidative Decarboxylation with Trichloroisocyanuric Acid},
  author={Gene A. Hiegel and Justin Cody Lewis and Jason W. Bae},
  journal={Synthetic Communications},
  pages={3449 - 3453}
Abstract Trichloroisocyanuric acid oxidation of α‐amino acids in water or methanol in the presence of pyridine produces nitriles with one less carbon in good yields and of high purity. 
16 Citations
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24種類のアミノ酸と塩素との水溶液中における反応生成物を各フラクションに分けて, GCおよびGC/MSを用いて同定を行った。揮発性有機塩素化合物として, 多くのアミノ酸からクロロホルム, 四塩化炭素, トリクロロエチレン, クロロピクリンが検出された。ペンタン抽出物質として, 各アミノ酸の炭素数が1個少ないアルデヒドおよびニトリルが検出された。またフェニルアラニンの場合,