Conversion from cyclosporine to mycophenolate mofetil improves expression of A20 in the rat kidney allografts undergoing chronic rejection.

@article{Teng2006ConversionFC,
  title={Conversion from cyclosporine to mycophenolate mofetil improves expression of A20 in the rat kidney allografts undergoing chronic rejection.},
  author={Dong-hai Teng and Y-m Lu and Rui Gao and Ya Ping Xin and Ge Cao and Xiangchun Li and J-g Wang and Luning Wang and Yan Li},
  journal={Transplantation proceedings},
  year={2006},
  volume={38 7},
  pages={
          2164-7
        }
}
AIMS Cytoprotective genes have shown to display potent anti-inflammatory and antiapoptotic functions in endothelial and smooth muscle cells. We investigated whether cytoprotective genes, especially A20, were involved in mycophenolate mofetil (MMF)'s ability to ameliorate transplant arteriosclerosis in an experimental chronic rejection model. METHODS Sprague-Dawley rat renal grafts were orthotopically transplanted into Wistar rats following the procedure of Kamada with our modification. The… CONTINUE READING
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