Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine.

@article{Blasko2008ConversionFC,
  title={Conversion from cognitive health to mild cognitive impairment and Alzheimer's disease: prediction by plasma amyloid beta 42, medial temporal lobe atrophy and homocysteine.},
  author={Imrich Blasko and Kurt Jellinger and Georg Kemmler and Wolfgang Krampla and Susanne Jungwirth and Ildigo Wichart and Karl Heinz Tragl and Peter Fischer},
  journal={Neurobiology of aging},
  year={2008},
  volume={29 1},
  pages={1-11}
}
The changes of plasma amyloid beta (Abeta42) protein, homocysteine and medial temporal lobe atrophy (MTA) were studied by the transition from cognitive health to mild cognitive impairment (MCI) and to Alzheimer's disease (AD) in a prospective cohort of individuals aged 75 years. MTA but not plasma Abeta42 measured at baseline predicted which persons remained cognitively healthy (CH) and who developed AD 2.5 years later. The increase of plasma Abeta42 over time significantly distinguished… CONTINUE READING

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