Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.

@article{Kernis1997ConversionBP,
  title={Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria.},
  author={Sophie Kern{\'e}is and Anna A Bogdanova and J. P. Kraehenbuhl and Eric Pringault},
  journal={Science},
  year={1997},
  volume={277 5328},
  pages={949-52}
}
The epithelium that lines the gut is impermeable to macromolecules and microorganisms, except in Peyer's patches (PPs), where the lymphoid follicle-associated epithelium (FAE) contains M cells that transport antigens and microorganisms. A cultured system that reproduces the main characteristics of FAE and M cells was established by cultivation of PP lymphocytes with the differentiated human intestinal cell line Caco-2. Lymphocytes settled into the epithelial monolayer, inducing reorganization… CONTINUE READING
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