Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection.

@article{Zagajewski2012ConversionLT,
  title={Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection.},
  author={Jacek Zagajewski and Danuta Drozdowicz and Iwona Brzozowska and Magdalena Hubalewska-Mazgaj and Teresa Stelmaszynska and Piotr M. Laidler and Tomasz Brzozowski},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2012},
  volume={63 6},
  pages={613-21}
}
Melatonin is a major biosynthetic product of pineal gland exerting a potent antioxidant and the reactive oxygen metabolites scavenging activities but the mechanism of formation of this indole at extrapineal sources has not been fully elucidated. It is known that the gastrointestinal (GI)-tract plays an important role as a source of melatonin synthesis but the conversion of L-tryptophan into melatonin in the GI-tract of experimental animals and humans should be further examined. In this study… CONTINUE READING
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Pineal, retinal and Harderian gland melatonin in a diurnal species, the Richardson's ground squirrel (Spermophilus richardsonii)

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