Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells

@article{Demirkiran2009ConversionFC,
  title={Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells},
  author={A. Demirkiran and V. Sewgobind and Joyce van der Weijde and A. Kok and C. Baan and J. Kwekkeboom and H. Tilanus and H. Metselaar and L. V. D. van der Laan},
  journal={Transplantation},
  year={2009},
  volume={87},
  pages={1062-1068}
}
Background. CD4+Foxp3+ regulatory T cells (Treg) depend on interleukin (IL)-2 for their function and survival. By interfering with the IL-2 production, calcineurin inhibitors (CNI) may negatively affect Treg. Here, we describe the effects of conversion from CNI to mycophenolate mofetil (MMF) monotherapy on renal function, and on Treg frequency and phenotype in liver transplant recipients. Methods. Patients (n=16) with renal impairment on CNI were converted to MMF and received a single dose of… Expand

Paper Mentions

Interventional Clinical Trial
As is well known, immunosuppressive treatment (IS) after liver transplantation has several and frequents adverse effects that limit the survival of the graft and recipients. Because of… Expand
ConditionsGene Expression, Immunosuppression Conversion, Liver Transplantation
InterventionDrug
Different Immunosuppressive Combinations on T-Cell Regulation in Renal Transplant Recipients
Induction of bona fide regulatory T cells after liver transplantation – the potential influence of polyclonal antithymocyte globulin
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 21 REFERENCES
Following Anti‐CD25 Treatment, A Functional CD4+CD25+ Regulatory T‐Cell Pool Is Present in Renal Transplant Recipients
...
1
2
3
...