Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells

@article{Demirkran2009ConversionFC,
  title={Conversion From Calcineurin Inhibitor to Mycophenolate Mofetil-Based Immunosuppression Changes the Frequency and Phenotype of CD4+FOXP3+ Regulatory T Cells},
  author={Ahmet Ender Demirkıran and Varsha D. K. D. Sewgobind and Joyce van der Weijde and Alice Kok and Carla C. Baan and Jaap Kwekkeboom and Hugo W. Tilanus and Herold Johnny Metselaar and Luc J.W. van der Laan},
  journal={Transplantation},
  year={2009},
  volume={87},
  pages={1062-1068}
}
Background. CD4+Foxp3+ regulatory T cells (Treg) depend on interleukin (IL)-2 for their function and survival. By interfering with the IL-2 production, calcineurin inhibitors (CNI) may negatively affect Treg. Here, we describe the effects of conversion from CNI to mycophenolate mofetil (MMF) monotherapy on renal function, and on Treg frequency and phenotype in liver transplant recipients. Methods. Patients (n=16) with renal impairment on CNI were converted to MMF and received a single dose of… 
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TLDR
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TLDR
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    Transplant international : official journal of the European Society for Organ Transplantation
  • 2012
TLDR
Although in vitro experiments confirm that rATG primarily led to a conversion of CD4+ CD25− into CD4- CD25+ T cells displaying immunosuppressive capacities, these cells cannot be classified as bona fide Treg based on their FOXP3 demethylation pattern and therefore the potential clinical relevance of these cells for transplant outcome remains to be determined.
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