Conversation with Raphael Mechoulam.

  title={Conversation with Raphael Mechoulam.},
  author={Raphael Mechoulam},
  volume={102 6},
In this occasional series we record the views and personal experience of people who have specially contributed to the evolution of ideas in the Journal’s field of interest. Entering what was, at the start, a neglected field, Raphael Mechoulam went on to pursue, over the next 40 years, a highly productive career in cannabis research. This interview charts a sequence of discoveries and reveals something of the dedication and intellectual daring which has characterized the enterprise throughout. 

From Bud to Brain: A Psychiatrist's View of Marijuana

The science all healthcare professionals need to know in order to provide objective and relevant information to a variety of patients, from recreational and medicinal users to those who use regularly, and to adolescents and worried parents is summarized.

Gastrointestinal Physiology

This chapter provides contemporary information on the historical timeline of events that transpired on GI physiology beginning from antiquity to the contemporary period to allow for meaningful future investigations that could fetch the world results for the betterment of life.

Contemporary Routes of Cannabis Consumption

  • Julianne Moy
  • Medicine
    The Journal of the American Osteopathic Association
  • 2019
I would first like to commend Peters and Chien on the concise information they provided regarding the modalities, forms, and dosing of cannabis in their February 2018 article, but strongly disagree and refute their statement that “Physicians have little reason to advocate for cannabis use, as data are limited on its beneficial effects.

Cannabis Use , Effect And Potential Therapy For Alzheimer ' s , MS and Parkinson ' s

  • Medicine
Cannabinoids and endocannabinoids are supposed to represent a medicinal treasure trove which waits to be discovered, but over the last decade they have been found to affect a long list of processes, from anxiety, depression, cancer development, vasodilatation to bone formation and even pregnancy.

Cannabinoids, Chemical Senses, and Regulation of Feeding Behavior

The CB1 receptor represents the most relevant target molecule of cannabinoid components on nervous system and whole-body energy homeostasis and can increase appetite and stimulate feeding, whereas blockade of CB1 suppresses hunger and induces hypophagia.

Endocannabinoids in Body Weight Control

The overall goal is to address the molecular, cellular and pharmacological logic behind central and peripheral eCB-mediated body weight control, and to figure out how these precise mechanistic insights are currently transferred into the development of next generation cannabinoid medicines displaying clearly improved safety profiles, such as significantly reduced side effects.

Endocannabinoids, cannabinoid receptors and inflammatory stress: an interview with Dr. Pál Pacher

  • H. Rosenberg
  • Biology, Medicine
    Journal of leukocyte biology
  • 2007
The role of the cannabinoid receptor 2 (CB2) agonist, HU-308, in preventing tissue damage in an experimental model of tissue ischemia / reperfusion injury is explored.

PET Studies of Neurotransmission in Temporal Lobe Epilepsy

PET Studies of Neurotransmission in Temporal Lobe Epilepsy show clear patterns of activity in the temporal lobe of the brain corresponding to EMT and EMT, and these patterns are associated with EMT-like symptoms in patients with TEP.



Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

strongly solvated than triple ions,lb-5 the difference being greater for cations of smaller radii, leading to a trend to smaller K with decreasing cationic radii. Both effects, in opposite

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.

Four of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition, while CBD was ineffective in 1 patient.

Isolation and structure of a brain constituent that binds to the cannabinoid receptor.

Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.

Data show that CBD, through its combined immunosuppressive and anti-inflammatory actions, has a potent anti-arthritic effect in CIA.

An endogenous cannabinoid (2-AG) is neuroprotective after brain injury

It is shown that, after injury to the mouse brain, 2-AG may have a neuroprotective role in which the cannabinoid system is involved and this effect was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor.

N-arachidonoyl l-serine, an endocannabinoid-like brain constituent with vasodilatory properties

  • G. MilmanY. Maor R. Mechoulam
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
ARA-S may represent an endogenous agonist for this receptor and produces endothelium-dependent vasodilation of rat isolated mesenteric arteries and abdominal aorta and stimulates phosphorylation of p44/42 mitogen-activated protein (MAP) kinase and protein kinase B/Akt in cultured endothelial cells.

Determination and characterization of a cannabinoid receptor in rat brain.

The criteria for a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue have been fulfilled.

Hashish. I. The structure of cannabidiol.