Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease.

@article{Vidal2011ConvergingPI,
  title={Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease.},
  author={Roberto Mauricio Vidal and Benjam{\'i}n Caballero and Andr{\'e}s Couve and Claudio Hetz},
  journal={Current molecular medicine},
  year={2011},
  volume={11 1},
  pages={1-12}
}
A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease and Parkinson's disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. Mutations leading to expansion of a poly-glutamine track in Huntingtin cause HD, and trigger its misfolding… CONTINUE READING