Converging on proline: the mechanism of WW domain peptide recognition

@article{Zarrinpar2000ConvergingOP,
  title={Converging on proline: the mechanism of WW domain peptide recognition},
  author={Ali Zarrinpar and Wendell A Lim},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={611-613}
}
Specific protein–protein interactions are essential for the precise transmission of information in eukaryotic signal transduction pathways. Surprisingly, however, only a small number of modular protein recognition domains mediate the majority of protein–protein connections1–3. Some of the most common classes of modular recognition domains are those that recognize proline-rich motifs4. These domain families include, among others, SH3, EVH1 and WW domains. The importance of this class of… CONTINUE READING

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