Converging evidence of mitochondrial dysfunction in a yeast model of homocysteine metabolism imbalance.

Abstract

An elevated level of homocysteine, a thiol amino acid, is associated with various complex disorders. The cellular effects of homocysteine and its precursors S-adenosylhomocysteine (AdoHcy) and S-adenosylmethionine (AdoMet) are, however, poorly understood. We used Saccharomyces cerevisiae as a model to understand the basis of pathogenicity induced by… (More)
DOI: 10.1074/jbc.M111.228072

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