Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.

  title={Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia.},
  author={Fuquan Zhang and Hua Fan and Yong Xu and Kerang Zhang and Xuezhu Huang and Yan Zhu and Manqiu Sui and Gaoxiang Sun and Kun Feng and Bo Xu and Xiaoqian Zhang and Zhonghua Su and Chunqing Peng and Pozi Liu},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  volume={156B 5},
The dopamine D3 receptor has been implicated in the pathophysiology of schizophrenia (SZ). A glycine-to-serine polymorphism at codon 9 of the dopamine D3 receptor gene (DRD3), rs6280, has been widely studied for its association with SZ, but with conflicting results. Altered levels of DRD3 mRNA have also been reported in SZ compared with normal controls. Moreover, it has been suggested that DRD3 is subject to recent positive selection in European populations. To explore the potential role of… CONTINUE READING
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