Converging effects of Ginkgo biloba extract at the level of transmitter release, NMDA and sodium currents and dendritic spikes.

  title={Converging effects of Ginkgo biloba extract at the level of transmitter release, NMDA and sodium currents and dendritic spikes.},
  author={Bernadett K. Sz{\'a}sz and Nora Lenkey and Albert M. I. Barth and Arpad Mike and Zsolt Somogyv{\'a}ri and Orsolya Farkas and Bal{\'a}zs Lendvai},
  journal={Planta medica},
  volume={74 10},
In this study, an attempt was made to integrate the effects of GINKGO BILOBA extract (GBE) in different experimental systems (IN VITRO cochlea, brain slice preparations and cortical cell culture) to elucidate whether these processes converge to promote neuroprotection or interfere with normal neural function. GBE increased the release of dopamine in the cochlea. NMDA-evoked currents were dose-dependently inhibited by rapid GBE application in cultured cortical cells. GBE moderately inhibited Na… Expand
Experimental evidence of Ginkgo biloba extract EGB as a neuroprotective agent in ischemia stroke rats
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The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex
The effects of acute and repeated oral administration of the standardized extract EGb 761® on extracellular levels of dopamine, noradrenaline and serotonin (5‐HT), and the dopamine metabolites 3,4‐dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the prefrontal cortex and striatum of conscious rats were examined. Expand
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Effect of Ginkgo Biloba Extract on N-Methyl-D-Aspartic Acid Receptor Subunit 2B Expression in a Salicylate-Induced Ototoxicity Model
EGb may play a role in regulating the GluN2B expression in the IC of salicylate-induced ototoxicity model, as shown in rats randomly allocated to control, SS, EGb, and EGb+SS groups. Expand
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WITHDRAWN: Comprehensive evaluation of neuroprotective effects of Ginkgo biloba extract EGB against ischemic stroke.
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