Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder

@inproceedings{Judy2013ConvergingEF,
  title={Converging Evidence for Epistasis between ANK3 and Potassium Channel Gene KCNQ2 in Bipolar Disorder},
  author={Jennifer Toolan Judy and Fayaz Seifuddin and Mehdi Pirooznia and Pamela B. Mahon and Dubravka Jancic and Fernando S. Goes and Thomas Schulze and Sven Cichon and Markus M. N{\"o}then and Marcella Rietschel and J Raymond Depaulo and James B. Potash and Peter P. Zandi},
  booktitle={Front. Genet.},
  year={2013}
}
Genome-wide association studies (GWAS) have implicated ANK3 as a susceptibility gene for bipolar disorder (BP). We examined whether epistasis with ANK3 may contribute to the "missing heritability" in BP. We first identified via the STRING database 14 genes encoding proteins with prior biological evidence that they interact molecularly with ANK3. We then tested for statistical evidence of interactions between SNPs in these genes in association with BP in a discovery GWAS dataset and two… CONTINUE READING
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