Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes virus countermeasures

@article{guedaPinto2021ConvergentLO,
  title={Convergent loss of the necroptosis pathway in disparate mammalian lineages shapes virus countermeasures},
  author={Ana {\'A}gueda-Pinto and Lu{\'i}s Q. Alves and Fabiana Neves and Grant McFadden and Bertram L Jacobs and Luis Filipe C. Castro and Masmudur Rahman and Pedro Jos{\'e} Esteves},
  journal={bioRxiv},
  year={2021}
}
Programmed cell death is a vital process in the life cycle of an organism. Necroptosis, an evolutionary restricted form of programmed necrosis, contributes to the innate immune response by killing pathogen-infected cells. This virus-host interaction pathway is organized around two key components: the receptor-interacting protein kinase 3 (RIPK3), which recruits and phosphorylates the mixed lineage kinase-like protein (MLKL), thus inducing cellular plasma membrane rupture and cell death… 
The evolution of regulated cell death pathways in animals and their evasion by pathogens
TLDR
The molecular pathways of regulated cell death, their roles in infection, and how they are perturbed by viruses and bacteria are reviewed, providing insights into the coevolution of host-pathogen interactions and cell death pathways.

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