Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.

@article{Zeltina2017ConvergentIS,
  title={Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization.},
  author={Antra Zeltina and Stefanie A. Krumm and Mehmet Furkan Şahin and Weston B. Struwe and Karl Harlos and Jack H. Nunberg and Max Crispin and Daniel D Pinschewer and Katie J. Doores and Thomas A Bowden},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 27},
  pages={
          7031-7036
        }
}
Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interaction by targeting the receptor-binding… CONTINUE READING

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