Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms.

@article{LeNiculescu2009ConvergentFG,
  title={Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms.},
  author={Helen Le-Niculescu and Sagar D Patel and Meenakshi Bhat and Ronald Kuczenski and Stephen V Faraone and Ming T. Tsuang and Francis J. McMahon and Nicholas J. Schork and John J I Nurnberger and Alexander B. Niculescu},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2009},
  volume={150B 2},
  pages={155-81}
}
Given the mounting convergent evidence implicating many more genes in complex disorders such as bipolar disorder than the small number identified unambiguously by the first-generation Genome-Wide Association studies (GWAS) to date, there is a strong need for improvements in methodology. One strategy is to include in the next generation GWAS larger numbers of subjects, and/or to pool independent studies into meta-analyses. We propose and provide proof of principle for the use of a complementary… CONTINUE READING
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