Convergent extension analysis in mouse whole embryo culture.


Mutations have been identified in a non-canonical Wnt signalling cascade (the planar cell polarity pathway) in several mouse genetic models of severe neural tube defects. In each of these models, neurulation fails to be initiated at the 3-4 somite stage, leading to an almost entirely open neural tube (termed craniorachischisis). Studies in whole embryo… (More)
DOI: 10.1007/978-1-61779-510-7_11


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