Convergent evolution of defensin sequence, structure and function

  title={Convergent evolution of defensin sequence, structure and function},
  author={Thomas M A Shafee and F. T. Lay and T. Phan and M. Anderson and M. Hulett},
  journal={Cellular and Molecular Life Sciences},
  • Thomas M A Shafee, F. T. Lay, +2 authors M. Hulett
  • Published 2016
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in their sequences and structures. Most display broad range antimicrobial activity at low micromolar concentrations, whereas others have other diverse roles, including cell signalling (e.g. immune cell recruitment, self/non-self-recognition), ion channel perturbation, toxic functions, and enzyme inhibition. The defensins consist of two… CONTINUE READING
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