• DOI:10.1007/s00018-016-2344-5
Corpus ID: 24741736

Convergent evolution of defensin sequence, structure and function

@article{Shafee2016ConvergentEO,
  title={Convergent evolution of defensin sequence, structure and function},
  author={Thomas M A Shafee and F. T. Lay and T. Phan and M. Anderson and M. Hulett},
  journal={Cellular and Molecular Life Sciences},
  year={2016},
  volume={74},
  pages={663-682}
}

Thomas M A Shafee, F. T. Lay, +2 authors M. Hulett

Published 2016

Biology, Medicine

Cellular and Molecular Life Sciences

Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in their sequences and structures. Most display broad range antimicrobial activity at low micromolar concentrations, whereas others have other diverse roles, including cell signalling (e.g. immune cell recruitment, self/non-self-recognition), ion channel perturbation, toxic functions, and enzyme inhibition. The defensins consist of two… CONTINUE READING

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