Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

@article{Marvig2015ConvergentEA,
  title={Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis},
  author={R. L. Marvig and L. Sommer and S. Molin and H. Johansen},
  journal={Nature Genetics},
  year={2015},
  volume={47},
  pages={57-64}
}
Little is known about how within-host evolution compares between genotypically different strains of the same pathogenic species. We sequenced the whole genomes of 474 longitudinally collected clinical isolates of Pseudomonas aeruginosa sampled from 34 children and young individuals with cystic fibrosis. Our analysis of 36 P. aeruginosa lineages identified convergent molecular evolution in 52 genes. This list of genes suggests a role in host adaptation for remodeling of regulatory networks and… Expand
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