Convergent Route to ent-Kaurane Diterpenoids: Total Synthesis of Lungshengenin D and 1α,6α-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione.

Abstract

The Hoppe's homoaldol reaction of a cyclo-hexenyl carbamate with an aldehyde followed by an unprecedented BF3·OEt2 mediated intramolecular Mukaiyama-Michael-type reaction affords the tetracyclic core structure of ent-kaurane diterpenoids. The usage of this convergent approach for assembling these natural products is demonstrated by the first asymmetric… (More)
DOI: 10.1021/jacs.7b00140

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Cite this paper

@article{Zhao2017ConvergentRT, title={Convergent Route to ent-Kaurane Diterpenoids: Total Synthesis of Lungshengenin D and 1α,6α-Diacetoxy-ent-kaura-9(11),16-dien-12,15-dione.}, author={Xiangbo Zhao and Wu Li and Junjie Wang and Dawei Ma}, journal={Journal of the American Chemical Society}, year={2017}, volume={139 8}, pages={2932-2935} }