Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis.

  title={Convergence of three steroid receptor pathways in the mediation of nongenotoxic hepatocarcinogenesis.},
  author={Michelle L O'Brien and Shamina M. Rangwala and Kenneth W Henry and Cary Weinberger and Dean C Crick and Charles J. Waechter and Dennis R. Feller and Daniel Noonan},
  volume={17 2},
The mechanisms by which peroxisome proliferators are able to regulate metabolic processes such as fat metabolism, while at the same time creating an environment for the development of hepatocellular carcinomas, is a central issue in the non-genotoxic carcinogenesis field. The convergence of two members of the steroid receptor family (peroxisome proliferator-activated receptor, PPAR; and retinoid X receptor, RXR) has provided strong support for an oxidative stress component in this… CONTINUE READING


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