Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses.

@article{Holstein2004ConvergenceOE,
  title={Convergence of excitatory and inhibitory hair cell transmitters shapes vestibular afferent responses.},
  author={Gay R Holstein and Richard D. Rabbitt and Giorgio P. Martinelli and Victor L. Jr. Friedrich and Richard Boyle and Stephen M. Highstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 44},
  pages={15766-71}
}
The vestibular semicircular canals respond to angular acceleration that is integrated to angular velocity by the biofluid mechanics of the canals and is the primary origin of afferent responses encoding velocity. Surprisingly, some afferents actually report angular acceleration. Our data indicate that hair-cell/afferent synapses introduce a mathematical derivative in these afferents that partially cancels the biomechanical integration and results in discharge rates encoding angular acceleration… CONTINUE READING