Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?

@inproceedings{Waters2016ConvergenceOS,
  title={Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?},
  author={Elaine M Waters and Sarah E Rowe and James P O'Gara and Brian P Conlon},
  booktitle={PLoS pathogens},
  year={2016}
}
The remarkable tolerance of bacterial biofilms to antimicrobial drugs underpins their role in chronic and recurring infections. Staphylococcus aureus biofilms are embedded in an extracellular matrix composed of self-produced extracellular polysaccharides, DNA, and proteins or host-derived matrices such as fibrin, prompting speculation that limited drug diffusion into biofilms contributes to tolerance. However, the slowand non-growing phenotypes of biofilm cells resemble those observed in the… CONTINUE READING
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