Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis

@article{Chan2008ConvergenceOM,
  title={Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis },
  author={Timothy A. Chan and Sabine Glockner and Joo Mi Yi and Wei Chen and Leander van Neste and Leslie M. Cope and James G. Herman and Victor E. Velculescu and Kornel E. Schuebel and Nita Ahuja and Stephen B. Baylin},
  journal={PLoS Medicine},
  year={2008},
  volume={5},
  pages={789 - 799}
}
BACKGROUND The identification and characterization of tumor suppressor genes has enhanced our understanding of the biology of cancer and enabled the development of new diagnostic and therapeutic modalities. Whereas in past decades, a handful of tumor suppressors have been slowly identified using techniques such as linkage analysis, large-scale sequencing of the cancer genome has enabled the rapid identification of a large number of genes that are mutated in cancer. However, determining which of… CONTINUE READING
68 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Similar Papers

Loading similar papers…