Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.

  title={Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.},
  author={Sabina Semiz and Jin Gyoon Park and Sarah M. C. Nicoloro and Paul S Furcinitti and Chuanyou Zhang and Anil Kumar Chawla and John Leszyk and M. Czech},
  journal={The EMBO journal},
  volume={22 10},
Insulin stimulates glucose uptake in muscle and adipose cells by mobilizing intracellular membrane vesicles containing GLUT4 glucose transporter proteins to the plasma membrane. Here we show in live cultured adipocytes that intracellular membranes containing GLUT4-yellow fluorescent protein (YFP) move along tubulin-cyan fluorescent protein-labeled microtubules in response to insulin by a mechanism that is insensitive to the phosphatidylinositol 3 (PI3)-kinase inhibitor wortmannin. Insulin… CONTINUE READING


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