Conventional immunosuppression is compatible with costimulation blockade-based, mixed chimerism tolerance induction.


T-cell costimulatory blockade has emerged as an effective strategy to prevent allograft rejection in experimental models. We and others have reported that the beneficial effects of costimulation blockade can be negated when combined with certain immunosuppressants. The current study evaluates the compatibility of various immunosuppressive agents in a… (More)