Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.

@article{Abe2007ConventionalDC,
  title={Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.},
  author={Kazumichi Abe and Kim P Nguyen and Sean D Fine and Ji-Hun Mo and Carol Shen and Steve S Shenouda and Maripat Corr and Steffen Jung and J. Scott Lee and Lars Eckmann and Eyal Raz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={17022-7}
}
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte… CONTINUE READING