Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.

@article{Plantinga2013ConventionalAM,
  title={Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.},
  author={Maud Plantinga and Martin Guilliams and Manon Vanheerswynghels and Kim Deswarte and Filipe Branco-Madeira and Wendy Toussaint and Leen Vanhoutte and Katrijn Neyt and Nigel Killeen and Bernard Malissen and Hamida Hammad and Bart M. Lambrecht},
  journal={Immunity},
  year={2013},
  volume={38 2},
  pages={322-35}
}
Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably separated CD11b(+) monocyte-derived DCs (moDCs) from conventional DCs (cDCs) and studied antigen uptake, migration, and presentation assays of lung and lymph node (LN) DCs in response to inhaled house dust mite (HDM). Mainly CD11b(+) cDCs but not CD103(+) cDCs induced T helper 2 (Th2) cell immunity in HDM-specific T… CONTINUE READING
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