Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances.

Abstract

We studied plasma levels and behavioural effects of a newly developed controlled release formulation of valproate (VPA-CR) in children with epilepsy. Valproate plasma levels and performances in attention and vigilance tasks were monitored during a 12-h period (daytime), both during monotherapy of conventional valproate (VPA) and 4 weeks after switching to a… (More)

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Cite this paper

@article{Brouwer1992ConventionalAC, title={Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances.}, author={Oebele F. Brouwer and M. S. M. Pieters and Peter M. Edelbroek and Antje Bakker and Anton Van Geel and Theo Stijnen and Aag Jennekens-Schinkel and Jan B K Lanser and Anja Peters}, journal={Epilepsy research}, year={1992}, volume={13 3}, pages={245-53} }