Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.

@article{Bamboat2010ConventionalDR,
  title={Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion.},
  author={Zubin M. Bamboat and Lee M. Ocuin and Vinod P. Balachandran and Hebroon Obaid and George Plitas and Ronald P. DeMatteo},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 2},
  pages={559-69}
}
TLRs are recognized as promoters of tissue damage, even in the absence of pathogens. TLR binding to damage-associated molecular patterns (DAMPs) released by injured host cells unleashes an inflammatory cascade that amplifies tissue destruction. However, whether TLRs possess the reciprocal ability to curtail the extent of sterile inflammation is uncertain. Here, we investigated this possibility in mice by studying the role of conventional DCs (cDCs) in liver ischemia/reperfusion (I/R) injury, a… CONTINUE READING