Convenient synthesis of a sialylglycopeptide-thioester having an intact and homogeneous complex-type disialyl-oligosaccharide.

@article{Kajihara2006ConvenientSO,
  title={Convenient synthesis of a sialylglycopeptide-thioester having an intact and homogeneous complex-type disialyl-oligosaccharide.},
  author={Yasuhiro Kajihara and Akiko Yoshihara and Kiriko Hirano and Naoki Yamamoto},
  journal={Carbohydrate research},
  year={2006},
  volume={341 10},
  pages={1333-40}
}
Access to glycopeptides with C-terminal thioester functionality is essential for the synthesis of large glycopeptides and glycoproteins through the use of native chemical ligation. Toward that end, we have developed a concise method for the synthesis of a glycopeptide thioester having an intact complex-type dibranched disialyl-oligosaccharide. The synthesis… CONTINUE READING