Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.

@article{Bikbulatov2007ConvenientSA,
  title={Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.},
  author={Ruslan V. Bikbulatov and Feng Yan and Bryan L. Roth and Jordan Kordian Zjawiony},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 8},
  pages={2229-32}
}
To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural kappa-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers. 

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Procedure for synthesis of 2-epi-2-thiosalvinorin A

  • R. V. Bikbulatov
  • Bioorg. Med. Chem. Lett
  • 2007

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