Convenient synthesis and diversification of dehydroalaninyl phosphinic peptide analogues.

@article{Matziari2001ConvenientSA,
  title={Convenient synthesis and diversification of dehydroalaninyl phosphinic peptide analogues.},
  author={Magdalini Matziari and Dimitris Georgiadis and Vincent Dive and Athanasios Yiotakis},
  journal={Organic letters},
  year={2001},
  volume={3 5},
  pages={659-62}
}
[structure: see text]. Dehydroalaninyl phosphinic dipeptide analogues were synthesized, via an efficient tandem Arbuzov addition/allylic rearrangement, in high yields. The susceptibility of the conjugate system to 1,4 nucleophilic additions was investigated. C-Elongation of the dipeptides was performed, and the efficiency of 1,4 addition to the resulting acrylamidic moiety was evaluated. Derivatization of such phosphinic templates is a powerful approach for rapid access to large number of… CONTINUE READING