Convenient Intermediates for the Preparation of C-4 Modified Derivatives of Pyrimidine Nucleosides.

@article{Miah1997ConvenientIF,
  title={Convenient Intermediates for the Preparation of C-4 Modified Derivatives of Pyrimidine Nucleosides.},
  author={A. Miah and C. Reese and Q. Song},
  journal={ChemInform},
  year={1997},
  volume={28}
}
In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues.
TLDR
Among the new series of derivatives, 3',5'-di-O-trityl-5-fluoro-2'-deoxyuridine was the most efficient in this series and inhibited both yellow fever virus and dengue virus replication with a 50% effective concentration (EC₅₀) of ∼1 μg/mL without considerable cytotoxicity. Expand
Commercial-Scale Synthesis of Protected 2′-Deoxycytidine and Cytidine Nucleosides
TLDR
Traditional triazolation method is better and suitable for commercial scale--up and p-nitrophenoxylation method is not suitable. Expand
Quest for a Cure: Potential Small-Molecule Treatments for COVID-19, Part 2
  • D. Hughes
  • Medicine
  • Organic Process Research & Development
  • 2021
TLDR
Synthetic work that has been recently published on remdesivir is updated, an overview of several routes to molnupiravir is provided, and classical routes to dexamethasone are reviewed, including some of those more recently developed. Expand
A concise route to MK-4482 (EIDD-2801) from cytidine.
TLDR
A two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an esterification and hydroxamination of cytidine that eliminates the need for protecting and activating groups and proceeds in overall yield of 75%, a significant advancement over the reported yield of 17%. Expand
5-Fluoro-2′-deoxycytidine as a Probe for the Study of B/Z-DNA Transition by 19F NMR Spectroscopy
TLDR
Circular dichroism experiments suggest that replacement of 2′- deoxycytidine with 5-fluoro-2′-deoxycyTidine does not lead to detectable conformational changes, either in the B- or Z-form, and B/Z-DNA transition induced by sodium chloride is likely initiated at terminal ends. Expand
2'-Deoxythymidine Adducts from the Anti-HIV Drug Nevirapine
TLDR
The data suggest that N3-NVP-dT may be formed in vivo and play a role in the hepatotoxicity and/or putative hepatocarcinogenicity of NVP. Expand

References

Convenient Intermediates for the Preparation of C-4 Modified Derivatives of Pyrimidine Nucleosides
Abstract 4-(4-Nitrophenoxy)-1-(βD-ribofuranosyl) pyrimidin-2(1H)-one 15, 5-methyl-4-(1, 2, 4-triazol-1-yl)-1-(βD-2-deoxyribofu-nosyl) pyrimidin-2(1H)-one 7a andExpand