Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.

@article{Mansukhani1997ConvenientNH,
  title={Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.},
  author={Mahesh M. Mansukhani and Kent L. Nastiuk and Hannina Hibshoosh and P Kularatne and Donna M Russo and John J. Krolewski},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={1997},
  volume={6 4},
  pages={229-37}
}
The ability to identify individuals who are predisposed to specific malignant tumors is a promising molecular diagnostic by-product of over two decades of intensive research into the genetic pathogenesis of human cancer. Approximately 2% of Ashkenazi Jews carry recurrent germline mutations in either the BRCA1 or BRCA2 genes that may predispose these individuals to the development of breast and ovarian cancer. We have developed a nonisotopic method, based on the formation of heteroduplexes… CONTINUE READING
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