Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application.

@article{Dancik2012ConvectiveTO,
  title={Convective transport of highly plasma protein bound drugs facilitates direct penetration into deep tissues after topical application.},
  author={Yuri Dancik and Yuri G. Anissimov and Owen G. Jepps and Michael S. Roberts},
  journal={British journal of clinical pharmacology},
  year={2012},
  volume={73 4},
  pages={564-78}
}
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Many products are applied to human skin for local effects in deeper tissues. Animal studies suggest that deep dermal and/or subcutaneous delivery may be facilitated by both dermal diffusion and transport via the cutaneous vasculature. However, the relationship between the extent and pathways of penetration, drug… CONTINUE READING