Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors

@article{Yang2009ConvectionED,
  title={Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors},
  author={Weilian Yang and Rolf Barth and Gong Wu and Tianyao Huo and Werner Tjarks and Michael J Ciesielski and Robert A. Fenstermaker and Brain D. Ross and Carol J. Wikstrand and Kent J. Riley and Peter J. Binns},
  journal={Journal of Neuro-Oncology},
  year={2009},
  volume={95},
  pages={355-365}
}
In the present study, we have evaluated a boronated dendrimer-epidermal growth factor (BD-EGF) bioconjugate as a molecular targeting agent for boron neutron capture therapy (BNCT) of the human EGFR gene-transfected F98 rat glioma, designated F98EGFR. EGF was chemically linked to a heavily boronated polyamidoamine dendrimer (BD) by means of the heterobifunctional reagent, mMBS. Biodistribution studies were carried out at 6 h and 24 h following intratumoral (i.t.) injection or intracerebral (i.c… CONTINUE READING
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