Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain

@article{Carty2010ConvectionenhancedDA,
  title={Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain},
  author={Nikisha Carty and Daniel Lee and Chad Dickey and Carolina Ceballos-Diaz and Kevin Nash},
  journal={Journal of Neuroscience Methods},
  year={2010},
  volume={194},
  pages={144-153}
}
The use of recombinant adeno-associated viral (rAAV) vectors as a means of gene delivery to the central nervous system has emerged as a potentially viable method for the treatment of several types of degenerative brain diseases. However, a limitation of typical intracranial injections into the adult brain parenchyma is the relatively restricted distribution of the delivered gene to large brain regions such as the cortex, presumably due to confined dispersion of the injected particles… CONTINUE READING

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