Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication.

@article{Cohen2016ConvallatoxinInducedRO,
  title={Convallatoxin-Induced Reduction of Methionine Import Effectively Inhibits Human Cytomegalovirus Infection and Replication.},
  author={Tobias S D Cohen and John D. Williams and Timothy J. Opperman and Roberto Sanchez and Nell S. Lurain and Domenico Tortorella},
  journal={Journal of virology},
  year={2016},
  volume={90 23},
  pages={
          10715-10727
        }
}
Cytomegalovirus (CMV) is a ubiquitous human pathogen that increases the morbidity and mortality of immunocompromised individuals. The current FDA-approved treatments for CMV infection are intended to be virus specific, yet they have significant adverse side effects, including nephrotoxicity and hematological toxicity. Thus, there is a medical need for safer and more effective CMV therapeutics. Using a high-content screen, we identified the cardiac glycoside convallatoxin as an effective… CONTINUE READING
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